Sfh-I, a subclass B2 metallo-beta-lactamase from a Serratia fonticola environmental isolate.
نویسندگان
چکیده
An environmental isolate of Serratia fonticola resistant to carbapenems was shown to contain a genetic determinant encoding a metallo-beta-lactamase of the subclass B2. The Sfh-I enzyme exhibits some divergence from the previously characterized enzymes of this subclass. This is the first example of a naturally occurring metallo-beta-lactamase in Enterobacteriaceae.
منابع مشابه
Molecular characterization of a carbapenem-hydrolyzing class A beta-lactamase, SFC-1, from Serratia fonticola UTAD54.
An environmental isolate of Serratia fonticola resistant to carbapenems contains a gene encoding a class A beta-lactamase with carbapenemase activity. The enzyme was designated SFC-1. The bla(SFC-I) gene is contained in the chromosome of S. fonticola UTAD54 and is absent from other S. fonticola strains.
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Serratia fonticola UTAD54 is an environmental isolate that is resistant to carbapenems due to the presence of a class A carbapenemase and a metallo-β-lactamase that are unique to this strain. Its draft genome sequence was obtained to clarify the molecular basis of its carbapenem resistance and identify the genomic context of its carbapenem resistance determinants.
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متن کاملSMB-1, a novel subclass B3 metallo-beta-lactamase, associated with ISCR1 and a class 1 integron, from a carbapenem-resistant Serratia marcescens clinical isolate.
A carbapenem-resistant Serratia marcescens strain, 10mdr148, was identified in a Japanese hospital in 2010. The carbapenem resistance of this strain was attributed to the production of a novel metallo-β-lactamase (MBL), named SMB-1 (Serratia metallo-β-lactamase). SMB-1 possessed a zinc binding motif, H(Q)XHXDH (residues 116 to 121), H196, and H263 and was categorized as a member of subclass B3 ...
متن کاملDraft Genome Sequence of a Clinical Isolate of Serratia marcescens, Strain AH0650_Sm1
Serratia marcescens strain AH0650_Sm1 is a clinical multidrug-resistant isolate from Australia. Here, we report its annotated draft genome comprising 20 contigs. We identified chromosomal antimicrobial resistance genes including a tet(41) variant, an aac(6')-Ic variant, ampC, a metallo-beta-lactamase, and several putative multidrug efflux pumps, as well as a novel prophage.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 47 7 شماره
صفحات -
تاریخ انتشار 2003